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-  2019 

Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion

DOI: https://doi.org/10.1016/j.chom.2019.02.007

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Abstract:

? P. aeruginosa keratitis infections result in biofilm formation on the cornea ? NETs form at the base of the biofilm, triggered by the type-3 secretion system (T3SS) ? NETs stop bacterial dissemination into the brain but promote antibiotic resistance ? Blocking exopolysaccharide Psl and the T3SS allowed neutrophils to break down the biofil

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