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OALib Journal期刊
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-  2019 

Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X

DOI: https://doi.org/10.1016/j.molcel.2019.01.015

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Abstract:

? Repeat B is required to spread Xist RNA, silence genes, and alter Xi 3D conformation ? Deleting Repeat B compromises recruitment of PRC1 and PRC2 ? Reciprocally, ablating PRC1 or PRC2 impairs Xist spreading ? Xist, PRC1, and PRC2 spread across the Xi in an interdependent manne

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