Beyond the Four Bases: A Home Run for Synthetic Epigenetic Control?

Park et al. (2019) Park M. Patel N. Keung A.J. Khalil A.S. Engineering Epigenetic Regulation Using Synthetic Read-Write Modules. Cell. 2019; 176 : 227-238.e20 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar create a synthetic self-propagating adenine methylation system for epigenetic control in human cells. Targeting adenine allows their modular system to act orthogonally to most epigenetic processes, thereby opening the door for novel methods of controlling gene expression