Human Spermatogonial Stem Cells Scrutinized under the Single-Cell Magnifying Glass

Spermatogonial stem cells (SSCs) are essential for adult spermatogenesis. Recently, Wang et al., 2018 Wang M. Liu X. Chang G. Chen Y. An G. Yan L. Gao S. Xu Y. Cui Y. Dong J. et al. Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis. Cell Stem Cell. 2018; 23 : 599-614.e4 Abstract Full Text Full Text PDF PubMed Scopus (0) Google Scholar , Guo et al., 2018 Guo J. Grow E.J. Mlcochova H. Maher G.J. Lindskog C. Nie X. Guo Y. Takei Y. Yun J. Cai L. et al. The adult human testis transcriptional cell atlas. Cell Res. 2018; 28 : 1141-1157 Crossref PubMed Scopus (3) Google Scholar , and Hermann et al. (2018) Hermann B.P. Cheng K. Singh A. Roa-De La Cruz L. Mutoji K.N. Chen I.C. Gildersleeve H. Lehle J.D. Mayo M. Westernstroer B. et al. The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids. Cell Rep. 2018; 25 : 1650-1667 e1658 Abstract Full Text Full Text PDF PubMed Scopus (2) Google Scholar used single-cell RNA sequencing to define and molecularly characterize human testicular cell populations, including spermatogonial subsets with characteristics of human SSCs