We Could Use More Tolerance: Role of Intestinal-Allograft-Derived Human Stem Cells

Mixed chimerism is associated with allograft acceptance and tolerance. In this issue of Cell Stem Cell, Fu et al. (2019) Fu J. Zuber J. Martinez M. Shonts B. Obradovic A. Wang H. Lau S.P. Xia A. Waffarn E.E. Frangaj K. et al. Human Intestinal Allografts Contain Functional Hematopoietic Stem and Progenitor Cells that Are Maintained by a Circulating Pool. Cell Stem Cell. 2019; 24 ( this issue) : 227-239 Google Scholar provide evidence that functional, donor-derived hematopoietic stem and progenitor cells in the intestinal allograft can persist long-term, contribute to multi-lineage chimerism in the circulation, and result in T cell tolerance through host lymphoid organ selection