Intestinal Damage Fades, but Insults Linger: Setting the Immunological Tone for Infection

Clostridium difficile has emerged as a noteworthy pathogen in patients with inflammatory bowel disease. In this issue of Cell Host & Microbe, Saleh et al. (2019) Saleh M.M. Frisbee A.L. Leslie J.L. Buonomo E.L. Cowardin C.A. Ma J.Z. Simpson M.E. Scully K.W. Abhyankar M.M. Petri Jr., W.A. Colitis-induced Th17 cells increase the risk for severe subsequent Clostridium difficile infection. Cell Host Microbe. 2019; 25 ( this issue) : 756-765 Google Scholar demonstrate that Th17 responses induced by acute colitis contribute to increased disease severity during subsequent C. difficile infection