The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

？ The microbiome is required for sexual dimorphism in gene expression and metabolism ？ Most already-described changes in GF mice are hallmarks of a feminized metabolism ？ Altered sexual maturation and GH secretion cause the damping of sexual dimorphism ？ Microbiota-derived metabolites and ghrelin likely drive these alteration