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-  2019 

Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism

DOI: https://doi.org/10.1016/j.chom.2019.01.005

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Abstract:

? TF loss frequently occurs during murine infections and drives host adaptation ? Hemizygosity of the EFG1 TF licenses a phenotypic transition in C. albicans cells ? Numerous clinical isolates are EFG1 hemizygous and thus can undergo this transition ? This “phenotypic switch” corresponds to mutational loss of EFG1 functio

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