Persistent Antibody Clonotypes Dominate the Serum Response to Influenza over Multiple Years and Repeated Vaccinations

？ Longitudinal profiling of anti-H1N1 serum antibodies (Abs) reveals persisting Abs ？ The persistent Abs on average account for >70% of the serum responses over 5 years ？ Most persistent Abs bind and neutralize a highly divergent H5N1 viral strain ？ Cross-neutralizing anti-influenza Abs can persist in the circulatio