Death Eaters Rely on Metabolic Signaling to Wield Anti-inflammatory Responses

Efferocytosis, the process by which dying or dead cells are removed by phagocytes, is essential to tissue homeostasis. However, how these “death eaters” or efferocytes coordinate phagocytosis with their immune function is incompletely understood. In this issue, Zhang et al. (2018) Zhang S. Weinberg S. DeBerge M. Gainullina A. Schipma M. Kinchen J.M. Ben-Sahra I. Gius D.R. Charvet L.Y. Chandel N.S. et al. Efferocytosis fuels requirements of fatty acid oxidation and the electron transport chain to polarize macrophages for tissue repair. Cell Metab. 2018; 29 ( this issue) : 443-456 Google Scholar reveal how metabolic signaling drives the anti-inflammatory responses of efferocytes to promote wound healing