A Role for the Insulin Receptor in the Suppression of Dengue Virus and Zika Virus in Wolbachia-Infected Mosquito Cells

？ Antibody microarray to investigate mosquito host cell signaling response to Wolbachia ？ Wolbachia-infected cells show downregulation of the host cell insulin receptor (IR) ？ Inhibition or silencing of IR impairs the replication of dengue and Zika viruses in vitro ？ Mosquitoes fed the IR inhibitor have impaired Zika virus replicatio