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-  2019 

Quantifying Drug Combination Synergy along Potency and Efficacy Axes

DOI: https://doi.org/10.1016/j.cels.2019.01.003

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Abstract:

? MuSyC is a synergy framework applicable to any metric of drug combination effect ? Unlike other methods, MuSyC decouples synergy of potency and efficacy ? It subsumes traditional synergy methods, resolving ambiguities and biases in the field ? MuSyC reveals optimal co-targeting strategies in NCSLC and melanom

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