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-  2019 

Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance

DOI: https://doi.org/10.1016/j.cels.2018.12.005

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Abstract:

? Amino acid biosynthesis enzymes do not normally operate at maximum capacity ? Allosteric feedback inhibition ensures that enzymes are overabundant ? Enzyme overabundance provides robustness against decreases in gene expressio

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