Post-Translational Protein Transport by the Sec Complex

Although it has been studied for 30 years, the mechanism by which secretory proteins are transported post-translationally into the endoplasmic reticulum (ER) has not yet been fully resolved. Recently published structures (Itskanov and Park, S cience 2019;363:84–87; Wu, X. et al. Nature 2019;566:136–139) of the heptameric secretory (Sec) complex which mediates post-translational import into the yeast ER shed new light on the process