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- 2019
HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor SuppressionDOI: https://doi.org/10.1016/j.isci.2019.02.008 Abstract: ？ MULE undergoes MDM2/HDAC2-mediated degradation in synovial sarcoma ？ HDAC inhibition promotes MULE stabilization by acetylation and dissociation of MDM2 ？ SS18-SSX fusion oncoprotein is a target of MULE E3 ligase ？ HDAC inhibitors downregulate SS18-SSX stability through the ubiquitin syste
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