Autism and Schizophrenia-Associated CYFIP1 Regulates the Balance of Synaptic Excitation and Inhibition

？ CYFIP1 and CYFIP2 are enriched at inhibitory synapses. ？ CYFIP1 upregulation differentially disrupts inhibitory and excitatory synapses. ？ Conditional loss of CYFIP1 alters neuroligin 3 and GABAAR β-subunits expression. ？ Loss of CYFIP1 increases inhibitory synaptic clusters and hence mIPSC amplitude