NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair

？ NR4A nuclear orphan receptors possess a poly-ADP-ribose (PAR)-binding pocket ？ PAR binding is essential to NR4A activity in DNA repair ？ Ionizing radiation induces PARylation of DNA-PKcs kinase ？ NR4As promote DNA-PKcs autophosphorylation in a PAR-dependent fashio