[Na+] Increases in Body Fluids Sensed by Central Nax Induce Sympathetically Mediated Blood Pressure Elevations via H+-Dependent Activation of ASIC1a

？ Na x-KO mice do not exhibit salt-sensitive hypertension induced by salt loading ？ Na x-positive glial cells in OVLT are activated by [Na +] increases in body fluids ？ Activated glial cells enhance H + release to activate ASIC1a-positive OVLT neurons ？ Activated OVLT(→PVN) neurons induce sympathetically mediated hypertension via RVL