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-  2019 

Vectorial Import via a Metastable Disulfide-Linked Complex Allows for a Quality Control Step and Import by the Mitochondrial Disulfide Relay

DOI: https://doi.org/10.1016/j.celrep.2018.12.092

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Abstract:

? IMS import by the disulfide relay proceeds via formation of a covalent intermediate ? Import is driven by hydrophobic and disulfide-dependent interactions ? The covalent intermediate is also formed by oxidation-incompetent substrates ? Redox quality control allows for IMS substrate release and proteasomal degradatio

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