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-  2019 

N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells

DOI: https://doi.org/10.1016/j.celrep.2018.12.093

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Abstract:

? rHSC and pHSCs are distinguished by their resistance or sensitivity to chemotherapy ? pHSCs in the perivascular niche are largely eliminated by chemotherapy ? rHSCs are maintained by N-cad+ cells and restore the HSC pool after chemotherapy ? N-cad+ BMSPCs expand and produce SCF and other cytokines for rHSCs upon stres

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