β Cell Hypoxia-Inducible Factor-1α Is Required for the Prevention of Type 1 Diabetes

？ Type 1 diabetes is increasing worldwide, which must be due to environmental changes ？ Lack of β cell HIF1a increases risk of T1D after viral infection ？ β Cell HIF1a also decreases T1D after low doses of the β cell toxin streptozotocin ？ β Cell HIF1a is a major factor in determining whether insult leads to T1D or resolutio