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-  2019 

Mitohormesis Primes Tumor Invasion and Metastasis

DOI: https://doi.org/10.1016/j.celrep.2019.04.095

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Abstract:

? Evidence of endogenous mitohormesis in breast cancer cell lines and primary tumors ? Mitohormetic priming of tumor cells leads to increased basal activation of the UPRmt ? Mitohormesis and UPRmt activation makes cancer cells more invasive and metastatic ? UPRmt enriched breast cancer patients have worse clinical outcome

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