Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation

？ Exome sequencing identifies genetic drivers of vein of Galen malformations (VOGMs) ？ Mutations in chromatin modifier and Ephrin genes account for ～30% of VOGM cases ？ Probands often exhibit vasculo-cutaneous lesions, suggesting a two-hit mechanism ？ These data implicate impaired arterio-venous specification in VOGM pathogenesi