Infectivity of Dengue Virus Serotypes 1 and 2 Is Correlated with E-Protein Intrinsic Dynamics but Not to Envelope Conformations

？ Mg 2+/Ca 2+ mediate the temperature-dependent partial reversibility in DENV2 morphology ？ MD show disruption of the inter-subunit salt bridges at the 5-fold vertex at ≥37°C ？ Loss of E-protein flexibility and intrinsic dynamics correlates to DENV2 infectivity ？ DENV2 and DENV1 show divergent morphological and intrinsic dynamic behavior