Tertiary Structural Motif Sequence Statistics Enable Facile Prediction and Design of Peptides that Bind Anti-apoptotic Bfl-1 and Mcl-1

？ Information in tertiary structural motifs is used to score protein complexes ？ Bcl-2 protein interactions are predicted and designed without atomistic modeling ？ Motif-based design generates high-affinity peptides quickly and reliably ？ High-resolution structures show how designs engage Bfl-1 and Mcl-