Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15

？ Tight and selective UbVs target USP15 catalytic and adaptor domains ？ UbV inhibitors lock the USP15 active site in an inactive conformation ？ A strand-swapped UbV dimer binds two DUSP domains simultaneously ？ Linear UbV dimers are potent and specific USP15 inhibitors in cell