Structural Basis of H+-Dependent Conformational Change in a Bacterial MATE Transporter

？ Crystal structures of VcmN, an H +-coupled MATE transporter from Vibrio cholerae ？ Distinct conformations associated with different pHs and the D35N mutation in TM1 ？ Coupling of rearrangement of hydrogen bond network around Asp35 to the TM1 bending ？ Common step in the transport cycle shared among prokaryotic H +-driven MATE protein