MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis

？ Blades II and IV insert into lipid head groups a loop characteristic of some MT-MMPs ？ Basic side chains at the bilayer-binding sites are drawn to lipid phosphoesters ？ Vesicles enhance digestion of collagen-like substrates by the MT1-MMP ectodomain ？ Binding of bilayers, collagen, CD44, and possibly dimerization are compatibl