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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

Complementary Activity of ETV5, RBPJ, and TCF3 Drives Formative Transition from Naive Pluripotency

DOI: https://doi.org/10.1016/j.stem.2019.03.017

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Abstract:

? Downstream of pErk, ETV5 initiates GRN handover during ESC transition ? RBPJ enforces naive pluripotency exit by preventing re-expression of NANOG or TBX3 ? ETV5 relocates to commission formative pluripotency enhancers ? ESCs lacking TCF3, ETV5, and RBPJ are trapped in a naive but nullipotent conditio

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