An X-ray Vision for Phosphoantigen Recognition

Invariant Vγ9Vδ2 T cells respond to “phosphoantigen” metabolites through binding to the B30.2 domain of butyrophilin BTN3A. Yang et al. (2019) Yang Y. Li L. Yuan L. Zhou X.J.D. Xiao H. Cai N. Han S. Ma X. Liu W. Chen C.-C. Wang L. et al. An atomic-level mechanism for phosphoantigen-mediated Vγ9Vδ2 activation. Immunity. 2019; 50 ( this issue) : 1043-1053 Abstract Full Text Full Text PDF Scopus (1) Google Scholar use molecular dynamic simulations based on X-ray structures of distinct B30.2 domain dimers to identify the asymmetric dimer as most active, which has implications for the inside-out signaling mechanism