Loss of p53 Causes Stochastic Aberrant X-Chromosome Inactivation and Female-Specific Neural Tube Defects

？ p53/Bim double knockout causes fully penetrant, female-specific neural tube defects ？ p53 binds to sites in the X chromosome inactivation center ？ Loss of p53 results in marked reduction of Xist RNA levels ？ Absence of p53 causes biallelic expression of X chromosome gene