Diminished Jak/STAT Signaling Causes Early-Onset Aging Defects in Stem Cell Cytokinesis

？ Failure of stem cell abscission is an early, age-induced defect in the testis ？ Jak/STAT signaling controls the block and reinitiation of abscission in stem cells ？ Compromising STAT activity precociously ages stem cells, inducing abscission failure ？ Abscission failure in stem cells disrupts tissue homeostasi