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-  2019 

A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus

DOI: https://doi.org/10.1016/j.chom.2018.11.011

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Abstract:

? Lectin CD169 limits systemic murine retrovirus dissemination from lymph node to spleen ? CD169 reduces virus spread and infection of erythroblast targets in red pulp of spleen ? CD169 promotes cross-presentation via cDC1 to elicit effective CD8+ T cell responses ? CD169?/? mice have defective antiretroviral CD8+ cytotoxic T cell respons

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