How Natural Killer Cell Receptors Stick to Cell–Cell Adhesion Proteins

The cytolytic activity of NK cells is regulated by activating and inhibitory receptors, including ones that recognize cell–cell adhesion molecules. In this issue of Structure, Deuss et al. (2019) Deuss F.A. Watson G.M. Fu Z. Rossjohn J. Berry R. Structural basis for CD96 immune receptor recognition of nectin-like protein-5 (CD155). Structure. 2019; 27 ( this issue) : 219-228 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar report the structure of nectin-like protein-5 bound to the NK inhibitory receptor CD96, a promising new target for cancer immunotherapy