Molecular Dissection of the Intrinsically Disordered Estrogen Receptor Alpha-NTD

In this issue of Structure, Peng et al. (2019) Peng Y. Cao S. Kiselar J. Xiao X. Du Z. Hsieh A. Ko S. Chen Y. Agrawal P. Zheng W. et al. A metastable contact and structural disorder in the estrogen receptor transactivation domain. Structure. 2019; 27 ( this issue) : 229-240 Abstract Full Text Full Text PDF PubMed Scopus (1) Google Scholar use a combination of computational modeling and solution-based experimental methods to characterize the intrinsically disordered N-terminal transactivation domain of estrogen receptor alpha. A long-range contact (I33-S118) was identified and was demonstrated to affect the protein conformation and coactivator binding