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-  2019 

Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα

DOI: https://doi.org/10.1016/j.str.2019.03.001

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Abstract:

? Structures of chimeric RIα 2:J-PKAcα 2 and wild-type RIα 2:PKAcα 2 holoenzymes are described ? The J domains in RIα 2:J-PKAcα 2 are highly dynamic ? RIα 2:PKAcα 2 has two distinct conformations ? The RIα holoenzyme structures differ from the wild-type RIβ and RIIβ holoenzyme

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