Beyond Purple Hearts: A Colorful Approach to Isolate Distinct Heart Cells from Human iPSCs

In this issue of Cell Stem Cell, Zhang et al. (2019) Zhang J.Z. Termglinchan V. Shao N.-Y. Itzhaki I. Liu C. Ma N. Tian L. Wang V.Y. Chang A.C.Y. Guo H. et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles. Cell Stem Cell. 2019; 24 ( this issue) : 802-811 Abstract Full Text Full Text PDF Scopus (1) Google Scholar describe a double-reporter iPSC line based on the expression of key cardiac transcription factors, TBX5 and NKX2.5, that delineates cardiac lineage specification in vitro and enables isolation of relatively pure chamber-specific cardiomyocytes, which are critical for drug screening, tissue engineering, and disease modeling