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-  2019 

Skin IL-17-Producing T Cells Support Repair 2!

DOI: https://doi.org/10.1016/j.it.2019.01.004

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Abstract:

In a recent study, Harrison et al. ( Science 2019;363;eaat6280) report that RORγt-expressing skin commensal-specific T cells rapidly respond to tissue wounding by producing type 2 T helper cell (Th2) cytokines in mice. The cells constitutively coexpress GATA-3 and type 2 cytokine mRNAs that are translated after injury. These T cells act as sentinels, linking T cell receptor (TCR) recognition of commensals, tissue damage, and wound repair

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