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-  2019 

Tumor-Derived Extracellular Vesicles Require β1 Integrins to Promote Anchorage-Independent Growth

DOI: https://doi.org/10.1016/j.isci.2019.03.022

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Abstract:

? sEVs from prostate cancer stimulate anchorage-independent growth of recipient cells ? sEVs from tumor bearing, but not healthy, mice contain β1 integrins ? sEV stimulation of anchorage-independent growth is dependent on β1 integrins ? β1 down-regulation in the prostate tumor epithelium impairs EV function

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