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OALib Journal期刊
ISSN: 2333-9721
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-  2019 

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

DOI: https://doi.org/10.1016/j.celrep.2019.02.056

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Abstract:

? Differential expression of cilia-annotated genes in islets of diabetic mice and humans ? Islets of control mice have more cilia, which disassemble under high glucose levels ? Pathway enrichment analysis links affected cilia genes to cell division ? Inhibition of KIF3A lowers islet cell replication in mice and human

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