It Takes a Matured mAb to Treat Ebolavirus Infection

Pan- Ebolavirus immunotherapy would provide a rapid-response treatment during Ebola virus outbreaks. In this issue of Cell Host & Microbe, Wec et al. (2019) Wec A.Z. Bornholdt Z.A. He S. Herbert A.S. Goodwin E. Wirchnianski A.S. Gunn B.M. Zhang Z. Zhu W. Liu G. et al. Development of a human antibody cocktail that deploys multiple functions to confer pan-ebolavirus protection. Cell Host Microbe. 2019; 25 ( this issue) : 39-48 Google Scholar and Bornholdt et al. (2019) Bornholdt Z.A. Herbert A.S. Mire C.E. He S. Cross R.W. Wec A.Z. Abelson D.M. Geisbert J.B. James R.M. Rahim M.N. et al. A two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates. Cell Host Microbe. 2019; 25 ( this issue) : 49-58 Google Scholar optimize the MBP134 mAb cocktail through antibody affinity maturation, improving its protective efficacy against three Ebolaviruses: EBOV, SUDV, and BDBV