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-  2019 

Complement C4 Prevents Viral Infection through Capsid Inactivation

DOI: https://doi.org/10.1016/j.chom.2019.02.016

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Abstract:

? Complement components C1 and C4 mediate potent neutralization of adenovirus ? Deposition of C4b on the viral capsid inactivates capsid disassembly ? C4 exerts direct antiviral functions independent from its role as a C3-convertase ? C4 antiviral functions synergize with TRIM21-mediated virus neutralizatio

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