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-  2019 

Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear

DOI: https://doi.org/10.1016/j.chom.2019.02.001

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Abstract:

? Cleaved inner ear cochlin LCCL secretes to perilymph space post-bacterial infection ? LCCL induces bacterial aggregation in the scala tympani ? Spatiotemporal innate immune response by LCCL protects the sensory organ of Corti ? LCCL rescues Coch ?/? mouse post- Pseudomonas inner ear infection hearing los

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