Internal Structure of Network Fluid Condensates Formed by Liquid-Liquid Phase Separation of a Multivalent Oligomeric Protein and a Disordered Linear Peptide

There is growing interest in uncovering the fundamental principles of liquid-liquid phase separation (LLPS) of multivalent proteins with intrinsically disordered regions, given the direct relevance to the reversible formation/dissolution of membraneless organelles and a wide range of other biomolecular condensates. However, despite recent advances, the multiscale structural characterization of liquid condensates has not yet been achieved