Expression of (pro)renin receptor and its effect on endothelial cell proliferation in infantile hemangioma

Propranolol is the preferred treatment for problematic proliferating infantile hemangioma (IH) by targeting the renin–angiotensin system (RAS) expressed by IH endothelium. (Pro)renin receptor (PRR) is a major component of the RAS associated with the canonical wnt signaling pathway. We proposed that activation of PRR by renin causes proliferation of IH