Drug Use Evaluation on Type 2 Diabetes Mellitus and Diabetic Nephropathy Inpatients in One of Hospitals in Tasikmalaya

Type 2 Diabetes mellitus (T2DM) is a degenerative disease and approximately 50% of patients with diabetes mellitus (DM) of more than 20 years’ duration also have diabetic nephropathy (DN). T2DM accounts for significant morbidity and mortality, however appropriate treatment can reduce the events. The objective of the study was to evaluate of drug use in inpatient T2DM and DN. This was a cross-sectional study with concurrent data retrieval on T2DM and DN inpatients in the period of March–June 2017 in one of hospitals in Taskimalaya, Indonesia. Forty-six patients were included in the study, of which 25 patients had T2DM and 21 had DN. The result of this study showed that appropriateness of drug selection reached 100% and 85.6% in T2DM and DN inpatients, respectively. Inappropriateness of drugs selection includes selection of ketorolac, ranitidine, folic acid, amlodipine and potassium containing drugs. Doses accuracy of T2DM patients reached 100% and of DN inpatients reached 92.1%. The inaccuracy of doses was due to the lack of dose adjustment to estimated glomerulus filtration rate (eGFR) level in each patient. Drugs interaction analysis showed a potential drug interaction on DN and T2DM which devided into major (13.8%; 7.2%), moderate (64.1%; 58%) and minor (22,1%; 34.8%). Based on the result, it is found an inappropriate drug selection and an inaccuracy of dose in DN patients, and a high percentage of drugs interaction on moderate classification in both diseases. It is necessary to optimize the role of pharmacist as a part of the healthcare team in the patient’s room to apply medication therapy management