Solvent free one pot synthesis of novel naphtho[1,8-gh] quinazoline-7,10-dione derivatives with CuCl2

The Biginelli-type reaction of phenalen-1,3-dione with urea, and benzaldehyde derivatives in the presence of CuCl2 as a catalyst for the synthesis of naphtho[1,8-gh]quinazoline-7,10-diones in solvent free condition are reviewed. Excellent yields of the products, short reaction times and simple work-up are attractive features of this suitable protocol.