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- 2018
In silico screening and biological evaluation of the compounds of Justicia gendarussa leaves extract as interferon gamma inducer: a study of anti Human Immunodeficiency Virus (HIV) developmentKeywords: The molecular docking test was performed by using Molegro Virtual Docker software to predict the interaction of alkaloid and flavonoid compounds of J. gendarussa leaves with IFN-γ receptor. In the in vivo test, the effects of 70% ethanol extract, fractionated 70% ethanol extract, and water extract of J. gendarussa leaves were evaluated on the profile of IFN-γ stimulation on mice (Mus musculus). The test was performed by administering the three gendarussa extracts into the nine groups of mice for 14 days. Abstract: Background: Justicia gendarussa Burm f. (Achanthaceae) has been known as traditional medicine in Indonesia. It contains of flavonoids and alkaloids. This study was conducted to evaluate the effect of J. gendarussa on the profile of IFN-γ on mice (Mus musculus). Molecular docking test was also conducted to determine the interaction of alkaloids and flavonoids on the J. gendarussa leaves against IFN-γ receptor. It is expected that this research will provide scientific information on the development of J. gendarussa leaves as an anti-HIV drug.
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