System Organization of Clinical Symptoms and EEG-Characteristics of Patients with Depressive Disorders in Harmonic Sound Therapy

The work is devoted to the search for the systemic organization of clinical symptoms and EEG characteristics of patients with recurrent depressive disorders. It determines the effect of harmonic sound in accordance with the extremes of the maximum and/or minimum EEG spectrum on clinical and EEG characteristics of patients, loosening of stable pathological relationships in order to reduce or eliminate depression. The study involved 58 patients. 35 of them were diagnosed with prolonged and chronic depressive disorder, which to no avail was treated with various antidepressants of the group of SSRIs in combination with benzodiazepines or small doses of atypical (olanzapine, sulpiride) or classical (chlorprotixen, sonapax) antipsychotics. At the time of sound therapy, the drugs were not canceled. 22 patients had repeated depressive episode in the past (two to four weeks ago), untreated. The search for the systemic organization of clinical symptoms and EEG characteristics was carried out using analytical mathematics. In this section factor analysis with factor rotation were used. The positive outcome of the sessions of sound exposure, as well as the reaction to the sound of the last session (no drowsiness or vigor, there is a weakening or elimination of depression), and the number of sessions depended on the removal of the most stable combinations of symptoms (according to the HAM- D scale). They reflected the reciprocity of their own symptoms of depression and anxiety in both groups of patients and made a "hard link" of the system. Other combinations of symptoms-flexible links of the system-are less stable. Acting on them in a stable pathological condition (depression) are less radical. Harmonic sound effects cause a significant restructuring of the background EEG observed at the time of exposure and after it in both groups of patients. The features of EEG in patients in complete or incomplete remission, as well as in the absence of the effect of treatment. Neurophysiological "hard link" of the system organization of EEG characteristics could not be identified. An attempt to explain the results is made. Perhaps the "hard link" of the system organization of EEG characteristics is at a different energy level or requires a different mathematical approach