Effects of Sperm Treatment on the Anti-sperm Antibodies IgG and IgA

Anti-sperm antibodies (ASA) form a class of glycoproteins commonly found in infertile men. This class of antibody causes an impairment of the spermatozoon's ability to cross cervical mucus and interact with the oocyte. The aim of our study was to analyze clinical and biological parameters of the sperm among positive ASA patients seen at the Center of Assisted Medical Procreation of the CHU Reunion before and after in-vitro treatment of autoimmune sperms. During the period from April 01, 2013 to February 29, 2015, we analyzed clinico-biological parameters of patients coming for exploring an infertility state with ASA IgG and IgA research before and after sperm treatment. Fourteen (1.51%) patients had a positive ASA, with a combination of ASA IgG and IgA for 71.42% of them. After in vitro treatment of the autoimmune sperm we found a persistence of IgA in 21.43% without IgG.